Abstract: OBJECTIVE To discuss the pathogenesis essence of Parkinson's disease through analyzing the distribution regularities of syndrome elements in 300 cases. METHODS Epidemiological cross-sectional survey method was applied to analyze the pathogenesis syndrome elements of 300 cases with Parkinson's disease and summarize its distribution characteristics. RESULTS The total appearance frequency of the eight kinds of syndrome elements was 1180， and the top four pathogenesis syndrome elements are wind， yin deficiency， phlegm and stasis， with the corresponding data being 22.88%， 22.12%， 14.89% and 17.54% respectively. The proportion of patients with the above two or more pathogenesis syndrome elements was 32.33%. CONCLUSION Liver-kidney yin deficiency is considered to be the basis of pathogenesis and wind-phlegm obstruction syndrome and stasis are the center pathogenesis， with the main syndrome type being liver-kidney yin deficiency and wind-phlegm obstruction. Hence， the main therapeutic method for this disease is to nourish liver and kidney， remove phlegm， eliminate wind and dredge collaterals.