Abstract: OBJECTIVE To observe the curative effect of Huangqi Guizhi Wuwu Decoction in the treatment of neuro-sensory toxicity caused by oxaliplatin. METHODS 48 cases of colorectal cancer were randomly divided into the control group (24 cases) treated with chemotherapy alone and the treatment group (24 cases) treated with Huangqi Guizhi Wuwu Decoction additionally. The neuro-sensory toxicity caused by oxaliplatin was judged by Levi standard. RESULTS Among 24 cases in treatment group， 8 cases presentedⅠclass， 1 patientⅡclass， and 0 patients Ⅲ / Ⅳclass， the total occurrence being 79.17%. In the control group， 13 cases presentedⅠclass， 3 patientⅡclass， 3 patients Ⅲ class and 0 case Ⅳclass. Compared with control group， there were less patients got Ⅲ/Ⅳ class toxic reaction in treatment group， which suggested a significant difference (P<0.01). CONCLUSION Huangqi Guizhi Wuwu Decoction has a significant effect on the neuro-sensory toxicity caused by oxaliplatin.