Abstract: OBJECTIVE To investigate the effects of integrative Chinese and western medicine on blood glucose， renal function and quality of life (QOL) in patients with Diabetic nephropathy DN in order to supply strategy for the treatment of early DN. METHODS 124 cases with early DN were randomly divided into western medicine group (n=62) and integrative group (n=62). The former were treated with western medicine and the latter were given Chinese medicine additionally for 3months. The levels of FPG， 2hPG， SUN， SCr and 24 h urine albumin quantitative and adverse reaction were evaluated in both groups and the QOL were measured by SF-36Scale. RESULTS The levels of FPG， 2hPG， SUN， SCr， and 24 h urine albumin quantitative were all significantly decreased after 3-month treatment than those in baseline (P<0.05) of which only SUN， SCr， and 24 h urine albumin were showed significant differences between the two groups(P<0.05). The incidence of adverse reaction was 20 97% in western medicine group， higher than 11.29% in integrative group (P<0.05) The scores in 8 fields of SF-36 Scale were all increased than baseline (P<0.05)， but the integrative group changed more (P<0.05). CONCLUSION Integrative Chinese and western medicine can obviously improve the patient's kidney function， reduce urinary protein， improve the patient's quality of life and reduce the adverse reaction in the treatment of early DN.