Abstract: OBJECTIVE To observe clinical effect of combination of Niaoduqing Granule and Huangkui on slowing down the progression of chronic renal failure during early stage. METHODS 116 cases diagnosed with early chronic renal failure were randomly divided into control group(58) and treatment groups A(28) and B(30)， respectively treated with Aixite， Niaoduqing Granule and combination of Niaoduqing Granule and Huangkui. The following indices were detected before and eight weeks after treatment， including serum creatinine(Scr)， endogenous creatinine clearance rate (Ccr)， blood urea nitrogen (BUN)， 24h urine protein， total cholesterol (TC)， triglyceride (TG)， high density lipoprotein (HDL-C)， low density lipoprotein (LDL-C). RESULTS After 8 weeks' treatment， group A and group B showed significant differences in all indices compared with those before treatment (P<0.05). Compared to the control group， there were significant differences of 24h urine protein， TC， TG， HDL-C and LDL-C in group A and B (P<0.05， P<0.01). There was significant difference between group A and B (P<0.05). As for clinical effect， group A and B showed significant difference， compared with control group (P<0.05). There was significant difference between the two groups (P<0.05).CONCLUSION Niaoduqing Granule combined with Huangkui is more effective to slow down the progression of chronic renal failure than Aixite by intervening the reversible factors causing malignant progression of renal function， such as excreating urine protein， regulating blood fat， reducing serum creatinine and blood urea nitrogen.