尿毒清联合黄葵延缓早期慢性肾衰竭进展的临床研究
Clinic Study on Niaoduqing Combined with Huangkui Slowing down the Progression of Chronic Renal Failure at Early Stage
-
摘要: 目的 观察尿毒清颗粒联合黄葵延缓早期慢性肾衰竭进展的临床疗效。方法 116例确诊为早期慢性肾衰竭的患者随机分为对照组（58例）和治疗A组（28例）、B组（30例）；分别给予爱西特、尿毒清及尿毒清联合黄葵治疗，于治疗前、治疗8周后分别检测患者血肌酐(Scr)、内生肌酐清除率(Ccr)、尿素氮(BUN)、24 h尿蛋白定量、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)。结果 3组治疗8周后，A、B组与治疗前相比，各指标均有显著性差异(P<0.05)；A、B组与对照组24 h尿蛋白定量、TC、TG、HDL-C、LDL-C有统计学差异(P<0.05，P<0.01)，A、B 2组比较，P<0.05。3组临床疗效比较，A、B与对照组比，P<0.05，A、B 2组比较，P<0.05。结论 尿毒清颗粒联合黄葵通过减少尿蛋白排出、调节血脂、降低血肌酐、尿素氮等多个影响肾功能恶性进展的可逆因素的干预，较爱西特更能延缓早期慢性肾衰竭的进展。Abstract: OBJECTIVE To observe clinical effect of combination of Niaoduqing Granule and Huangkui on slowing down the progression of chronic renal failure during early stage. METHODS 116 cases diagnosed with early chronic renal failure were randomly divided into control group(58) and treatment groups A(28) and B(30)， respectively treated with Aixite， Niaoduqing Granule and combination of Niaoduqing Granule and Huangkui. The following indices were detected before and eight weeks after treatment， including serum creatinine(Scr)， endogenous creatinine clearance rate (Ccr)， blood urea nitrogen (BUN)， 24h urine protein， total cholesterol (TC)， triglyceride (TG)， high density lipoprotein (HDL-C)， low density lipoprotein (LDL-C). RESULTS After 8 weeks' treatment， group A and group B showed significant differences in all indices compared with those before treatment (P<0.05). Compared to the control group， there were significant differences of 24h urine protein， TC， TG， HDL-C and LDL-C in group A and B (P<0.05， P<0.01). There was significant difference between group A and B (P<0.05). As for clinical effect， group A and B showed significant difference， compared with control group (P<0.05). There was significant difference between the two groups (P<0.05).CONCLUSION Niaoduqing Granule combined with Huangkui is more effective to slow down the progression of chronic renal failure than Aixite by intervening the reversible factors causing malignant progression of renal function， such as excreating urine protein， regulating blood fat， reducing serum creatinine and blood urea nitrogen.
-
Keywords:
- chronic renal failure /
- Niaoduqing /
- Huangkui
-
-
[1] 黎磊石，刘志红.中国肾脏病学[M].北京：人民军医出版社，2008:1269-1288. [2] Li LS， Liu ZH. China Nephrology[M]. Beijing: People's Millitary Medical Press， 2008:1269-1288. [3] 中药新药临床研究指导原则(试行)[S]. 北京：中国医药科技出版社， 2002：163-167. [4] Guideline for clinical trials of newly-developed drug of Chinese material medica[S]. Beijing: China medical science press， 2002:163-167. [5] 吕文琦.大黄合剂并低蛋白饮食治疗慢性肾衰竭的临床观察[J].中国中西医结合肾病杂志，2002， 3（6）：343-344. [6] Lv WQ. Clinic observation on combination of rhubarb mixture and low-protein diet treating chronic renal failure[J]. Chin J Integr Tradit West Nephr， 2002，3(6):343-344. [7] 庄永泽，谢福安，陈建.尿毒清颗粒冲剂治疗慢性肾衰竭的疗效观察及影响因素分析[J].中国中西医结合肾病杂志，2003，4（7）：402-403. [8] Zhuang YZ， Xie FA， Chen J.Therapeautic effect of Niaoduqing granule on chronic renal failure and influencial factors[J]. Chin J Integr Tradit West Nephr， 2003，4(7):402-403. [9] 胡志娟，郭岚，史亚男，等.尿毒清颗粒对单侧输尿管梗阻大鼠肾间质纤维化中氧化应激变化的影响[J].中国老年学杂志，2011， 31（24）：4849-4851. [10] 〖JP2〗Hu ZJ， Guo L， Shi YN， et al. Effect of Niaoduqing granule on oxidant stress in unilateral obstruction in acatalasemic mice with renal interstitial fibrosis[J]. Chin J Geriatr， 2011，31(24):4849-4851.〖JP〗 [11] 徐延平，宋剑，李彦华，等.黄葵胶囊对5/6肾切除大鼠肾间质纤维化中炎性因子表达的影响[J].中国中西医结合肾病杂志，2012， 6（6）：533-534. [12] Xu YP， Song J， Li YH，et al. Effect of Huangkui capsule on expression of inflammatory factors in 5/6 nephrectomy mice with renal interstitial fibrosis[J]. Chin J Integr Tradit West Nephr， 2012，6(6):533-534.
计量
- 文章访问数: 655
- HTML全文浏览量: 9
- PDF下载量: 698
下载:
