Abstract: OBJECTIVE To discuss the clinical efficiency of Jiedu Quyou Fang in the treatment of multiple verruca plantaris. METHODS 60 cases were collected from Department of Dermatology in Jiangsu Provincial Hospital of Traditional Chinese Medicine and were randomly divided into the treatment group (30 cases) and the control group (30 cases).The treatment group took the powder of Jiedu Quyou Fang by local hyperthermic soaking，while the control group had soaking and tretinoin cream. Patients in each group received treatment every night for 4 weeks as one course. After 1 to 3 courses' continuous treatment， the clinical effects and changes were evaluated. RESULTS 7 cases fully recovered， 9 cases had obvious effect， 10 cases improved， 4 cases had no effect in the treatment group， and the total effective rate was 86.67%. In the control group，no case fully recovered， 2 cases had obvious effect， 9 cases became better， 19 cases had no effect and the total effective rate was 36.67%. The curative effect of the treatment group was better than that of the control group. With statistical analysis， the integral index and overall efficacy difference of both groups had statistical significance (P<0.05). CONCLUSION Jiedu Quyou Fang， which is simple and cheap， can effectively treat the multiple plantar warts without trauma， worth of clinical application.