Abstract: OBJECTIVE To analyze clinical symptoms and signs distribution in 1 266 HIV/AIDS cases for laying the foundation of further clinical studies. METHODS The information on 1 266 HIV/AIDS cases selected from October 2004 to October 2009 was processed and made a statistical analysis. RESULTS Among the 1 266 cases， male took up 48.3% while female 51.7% with the ratio of 0.93∶1. Adults from 31 up to 40 years old accounted for 45.9% as the most. The majority were infected through blood transfusion， occupying 87.7%， manifesting fatigue， pale tongue and white coating and thin pulse as the main symptoms. CONCLUSION HIV/AIDS patients are mainly infected with blood transfusion. HIV/AIDS patients manifest with deficient syndromes and signs with qi deficiency as the basis and spleen as the pivot.