虚燥更平散治疗女性更年期原发性高血压病临床研究
Clinical Study of Xuzao Gengping Powder Treating Female Climactic Primary Hypertension
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摘要: 目的 从动态血压观察虚燥更平散治疗女性更年期原发性高血压病的临床疗效。方法 选取2008年3月至2009年10月新疆维吾尔自治区中医院高血压科门诊就诊的92例更年期高血压病阴虚内燥证患者随机分成治疗组48例和对照组44例，分别于治疗前后进行24 h动态血压监测(ABPM)，分析对血压变异及血压节律的影响。结果 ①与对照组比较，治疗组除24 h舒张压变异（24 hDSD）差异无统计学意义外（P＞0.05），24 h收缩压变异（24 hSSD）、白天收缩压变异（dSSD）、白天舒张压变异（dDSD）、夜间收缩压变异（nSSD）、夜间舒张压变异（nDSD）均有统计学意义（P<0.05）；②与对照组比较，治疗组平均血压除24 h平均舒张压（24 hDBP）、白天平均舒张压（dDBP）差异无统计学意义外（P＞0.05），24 h平均收缩压（24 hSBP）、白昼平均收缩压（dSBP）、夜间平均舒张压（nDBP）、夜间平均收缩压（nSBP）均减小，有统计学意义（P<0.05）；治疗组血压疗效总有效率高于对照组，有统计学意义(P<0.05)。夜间血压下降率明显上升，有统计学意义(P<0.05)。结论 虚燥更平散治疗更年期高血压病可调节血压节律，减小其血压变异性，明显降低收缩压水平，尤其对夜间血压变异的影响更为明显。Abstract: OBJECTIVE To observe clinical efficacy of Xuzao Gengping Powder Treating female climacteric primary hypertension by ambulatory blood pressure. METHODS Selected 92 patients treated in Hypertension Department of Xinjiang Uygur Autonomous Region Traditional Chinese Medicine Hospital from March 2008 to October 2009. 92 cases of climacteric hypertension with internal dryness due to yin deficiency were randomly divided into 48-case treatment group and 44-case control group. 24-hour ambulatory blood pressure monitoring (ABPM) was performed before and after treatment and effect of treatment on blood pressure variability and rhythm were analyzed. RESULTS ①Compared with control group， only 24h diastolic blood pressure variation(24h DSD/DBPV) in treatment group had no statistical significance(P>0.05). 24h systolic blood pressure variation(24h SSD/SBPV)， day systolic blood pressure variation(d SSD/SBPV)， day diastolic blood pressure variation(d DSD/DBPV)， night systolic blood pressure variation(n SSD/SBPV)， night diastolic blood pressure variation(n DSD/DBPV) all had statistical significance(P<0.05). ②Compared with control group， average blood pressure expect 24h average diastolic blood pressure(24h DBP) and day average diastolic blood pressure(d DBP) in treatment group had no statistical significance(P>0.05). 24h average systolic blood pressure(24h SBP)， day average systolic blood pressure(d SBP)， night average diastolic blood pressure(n DBP)， night average systolic blood pressure(n SBP) all decreased， had statistical significance(P<0.05). As to blood pressure therapeutic effect， the total effective rate of treatment group was higher than that of control group and had statistical significance(P<0.05). Night blood pressure decrease rate ascended obviously and had statistical significance(P<0.05). CONCLUSION Xuzao Gengping Powder treating climacteric hypertension can adjust blood pressure rhyme， decrease blood variability and reduce level of systolic blood pressure obviously. Particularly， it has significant effect on night blood pressure variation.
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