小叶菝葜不同部位提取物抗炎镇痛活性比较
Comparision on Analgesic and Anti-inflammatory Actions of the Extracts from Different Parts of Smilax Microphylla
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摘要: 目的 研究比较小叶菝葜不同部位提取物的抗炎、镇痛活性。方法 采用二甲苯致小鼠耳肿胀和蛋清诱发的大鼠足肿胀实验以及醋酸致小鼠扭体法实验研究抗炎、镇痛药理作用。结果 小叶菝葜乙醇提取的总浸膏、石油醚部位和乙酸乙酯部位均可降低二甲苯所致的小鼠耳肿胀度和蛋清诱发的大鼠足肿胀，乙酸乙酯部位效果最为显著；总浸膏和乙酸乙酯部位能明显的减少小鼠的扭体次数。结论 小叶菝葜乙醇总浸膏具有抗炎、镇痛作用，萃取后乙酸乙酯部位的抗炎、镇痛作用最为明显。Abstract: OBJECTIVE To study and compare the analgesic and anti-inflammatory actions of the extracts from different parts of smilax microphylla.METHODS Experiments， such as mice ear engorgement induced by dimethyl benzene and swelling of feet in rats induced by albumen and twisting response of mice induced by acetic acid method， were performed to study the pharmacological actions of analgesic and anti-inflammatory.RESULTS Smilax microphylla ethanol extract， petroleum ether and ethyl acetate extract could reduce mice ear engorgement induced by dimethyl benzene and swelling of feet in rats induced by albumen， especially ethyl acetate extract for its significant effects. The ethanol extract and ethyl acetate extract induced the number of the twisting response of mice obviously.CONCLUSION Smilax microphylla ethanol extract shows anti-inflammatory and analgesic actions and the effect of the extracted ethyl acetate extract is the most significant.
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Keywords:
- smilax microphylla /
- extracts /
- anti-inflammatory effect /
- analgesic effect
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