Abstract: OBJECTIVE To study and compare the analgesic and anti-inflammatory actions of the extracts from different parts of smilax microphylla.METHODS Experiments， such as mice ear engorgement induced by dimethyl benzene and swelling of feet in rats induced by albumen and twisting response of mice induced by acetic acid method， were performed to study the pharmacological actions of analgesic and anti-inflammatory.RESULTS Smilax microphylla ethanol extract， petroleum ether and ethyl acetate extract could reduce mice ear engorgement induced by dimethyl benzene and swelling of feet in rats induced by albumen， especially ethyl acetate extract for its significant effects. The ethanol extract and ethyl acetate extract induced the number of the twisting response of mice obviously.CONCLUSION Smilax microphylla ethanol extract shows anti-inflammatory and analgesic actions and the effect of the extracted ethyl acetate extract is the most significant.