Abstract: OBJECTIVE To observe influence of clearing heat， cooling blood and relieving toxin method on blood coagulation of patients bitten by long-noded pit viper. METHODS There were totally 69 cases of patients bitten by long-noded pit viper in Guilin Hospital of Traditional Chinese Medicine from May 2008 to May 2012， who were randomly divided into control group (36 cases) and treatment group (33 cases). The control group used the conventional treatment， while the treatment group added Xijiao Dihuang Decoction and Wuwei Xiaodu Decoction. Platelet (PLT)， thrombin time (TT) and prothrombin time (PT)， activated part clotting live enzyme time (APTT) and fibrinogen (FIB) of patients in two groups were observed 12， 24， 36 and 48 hours after administration. RESULTS PLT， TT， PT， APTT and FIB were not significantly different 12 hours after administration. But after 24 hours， PLT， TT and APTT in treatment group were statistically significant compared with control group (P<0.05). TT and APTT of two groups at 36th hour were statistically significant (P<0.05). Blood coagulation functions in two groups at 48th hour were basically returned to normal level. The rising trend of PLT in treatment group from 12h to 24h was more obvious compared with control group， while the change tendency of FIB in two groups was similar. TT and APTT in treatment group from 24th to 36th hour declined more apparently than control group. The change trend of PT in two groups did not show significant difference. CONCLUSION Clearing heat， cooling blood and relieving toxin method promotes the blood coagulation function recovery of patients bitten by long-noded pit viper.