Abstract: Phlegm-wet block is associated with the formation of phlegm-wet constitution，and also it is a kind of pathogenic factors， which can block qi-blood flowing，affect the function of organs，and finally result in Metabolic and cerebrovascular diseases. Increased oxidative stress is a key pathophysiological feature of those diseases， and the early antioxidant therapy can prevent them. This paper discusses the relationship between phlegm-wet constitution and oxidative stress from aspects of influencing factors and pathogenic mechanism， and holds that there are many similar influence factors between phlegm-wet constitution and oxidative stress ，such as life style， sports and age，etc. The decrease of antioxidant ability may be the formation basis of phlegm-wet constitution，the imbalance of redox may play an important role in the pathogenesis of phlegm-wet constitution，and oxidative damage may be the intrinsic mechanism which relate to the pathogenic diversity of phlegm-wet constitution. Exploring phlegm-wet constitution through oxidative stress can provide the important basis for disease prevention.