Abstract: This paper collected and introduced the clinical experiences of national TCM master Xuan Guowei in treating pemphigus by stages. Xuan Guowei argued that in the acute stage， the main syndrome was intense heat toxin and mainly treated by resolving toxins and dispelling pathogen. With the development of the disease course， warm-febrile pathogen would change into dryness， burning fluid and consuming qi and thus in the later stage， yin deficiency accompanied with dampness-heat was mostly seen. It should be treated by dispelling dampness and fortifying the spleen， as well as clearing heat and nourishing yin. The disease has a relapsing course and could be easily conversed into the impairment of yin and deficiency of qi. Xuan advocated the combination of Chinese and western medicine for the treatment of pemphigus. On the basis of hormone therapy， the external treatment of Chinese medicine according to different stages of the disease could further be added.