Abstract: OBJECTIVE To observe the clinical effects of the combined acupuncture and thunder-fire moxibustion in the treatment of female patient with chloasma. METHODS Seventy-eight female patients with chloasma were randomly divided into the treatment group and the control group， 9 cases in each group. The treatment group was treated with the combined acupuncture and thunder-fire moxibustion， and the control group was treated with orally taking VitC and VitE， 12 weeks as a course. Indicator changes such as skin lesion area， skin color， estrogen estradiol (E₂) and progesterone (P) were observed in two groups before and after treatment. RESULTS The total effective rate of the treatment group and the control group was 82.1% and 61.5% respectively after the treatment， and the therapeutic effect of the treatment group was better than that of the control group(P<0.05). Skin lesions improvement in the treatment group was better than that of the control group(P<0.05). E₂ levels decreased in two groups and P levels in two groups increased(P<0.05~0.01)， and the treatment group was better than the control group(P<0.05). Dermatology life quality index improvement in the treatment group was significantly better than that of the control group(P<0.05). CONCLUSION The combined acupuncture and thunder-fire moxibustion treatment has better curative effects than western medicine treatment group， and it can regulate E₂ and P levels， which deserves wild application in clinical practice.