Abstract: OBJECTIVE To investigate the postoperative life quality， anxiety and depression conditions of the patients with percutaneous coronary intervention (PCI) as well as its efficacy and safety. METHODS Fifty-nine cases with dual anxiety and depression were selected based on Zung self-rating anxiety scale(SAS) and self-rating depression scale(SDS)， and they were randomly divided into the treatment group (40 cases) and the control group (19 cases) according to the ratio of 2∶1. Both groups were given CHD conventional secondary prevention treatment， with Yixinshu capsule being added to the treatment group. Hamilton Anxiety scale(HRSD)， Hamilton depression scale (HAMA) and SF36 scores were performed during the first， second and third month of their hospitalization. RESULTS The anxiety and depression were both improved significantly in two groups. HRSD and HAMA scores before and after treatment were very different from each other(P<0.05~0.01 )， and the treatment group was better than the control group (P<0.05). In the comparison of scores of physiological function， social function， physical limitations and vitality， physical pain and general health of SF36 before and after treatment， the treatment group was better than the control group (P<0.05). CONCLUSION Yixinshu capsule can relieve patients' anxiety and depression after PCI intervention and improve their life quality， without causing severe adverse events.