Abstract: Migraine is an independent disease characterized by periodic attacks. As the pathogenesis features， blood deficiency and liver hyperactivity as well as the waxing-waning and transformation of each other exist throughout the whole process of migraine. Therefore， nourishing the blood and calming the liver are put forward as the treatment principle. The key pathogenesis in the attacking stage lies in the wind-yang harassing the upper body， which is mainly treated by dispelling wind and calming the liver， assisted by nourishing the blood and emolliating the liver; With root deficiency and branch excess as the pathogenesis in the intermittent stage， migraine is treated by nourishing the blood and calming the liver， while accompanying syndromes are treated according to their different patterns. The treatment principle of nourishing the blood and calming the liver should be followed strictly.