强心康对LVEF降低性心衰患者BNP、RDW水平的影响
Effect of QiangXinKang on BNP and RDW Level of patients with Heart Failure with Reduced LVEF
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摘要: 目的 通过观察强心康对左室射血分数（LVEF）降低性心力衰竭(简称心衰)患者血清脑钠肽（BNP）及红细胞体积分布宽度（RDW）浓度的影响，探讨强心康在慢性LVEF降低性心衰治疗中可能的作用靶点。方法 将符合LVEF降低性心衰诊断标准的患者198例，随机分为试验组102例，对照组96例。2组均依据《中国心力衰竭诊断和治疗指南2007》给予慢性心衰常规治疗；试验组在常规治疗基础上加用强心康。4周后比较2组治疗前后BNP、RDW水平及LVEF变化情况。结果 随着LVEF改善，治疗后2组患者血清BNP浓度及RDW水平均较治疗前下降，而以治疗组降低明显，2组间具有显著性差异（P＜0.05）。结论 强心康可显著降低LVEF降低性心衰患者血清BNP及RDW水平，改善LVEF降低性心衰患者的心功能。Abstract: OBJECTIVE This paper is to discuss possible targets in the treatment of heart failure with reduced left ventricular ejection fraction (HFREF) with QiangXinKang by observing the effect of QiangXinKang on the brain natriuretic peptide (BNP) and red blood cell volume distribution width (RDW) of patients with HFREF. METHODS 198 patients meeting the selecting criteria of HFREF were randomly divided into the experimental group with 102 cases and the control group with 96 cases. Both groups received routine treatments conforming to Guideline for the Diagnosis and Treatment for Heart Failure (2007 Edition) and the experimental group took QiangXinKang additionally. After 4-week treatment， changes of BNP， RDW level and LVEF were compared between the two groups before and after treatment. RESULTS As LVEF was improved after treatment， BNP concentration and RDW level of patients in both groups were significantly reduced， while those of the experimental group decreased more significantly， which showed a significant difference between the two groups (P<0.05). CONCLUSION QiangXinKang may significantly reduce the BNP and RDW level and improve the heart function of patients with HFREF.
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