Abstract: OBJECTIVE To study the clinical effect of Salpingocatheterism combined with Chinese medicine liquid irrigation under endoscope for chronic secretory otitis media (CSOM). METHODS From September 2012 to March 2014， 80 patients with CSOM(120 ears) in the clinic were randomly divided into two groups. The experimental group：40 cases(61ears) were treated with Salpingocatheterism combined with Chinese medicine liquid irrigation and the liquid named Qingqiao tang(empirical recipe) was injected for 4 to 7days with 2ml each time. The control group：40 cases(59ears) were treated by myingotomy with grommet insertion. The ventilation tube was generally pulled out after 6 to 8 weeks or dropped out by itself .All patients were followed up for 6 months and the effects were to be evaluated. RESULTS In the experimental group，among 61ears， 50 ears were cured，6 showed effectual results， 2 were positive to the treatment and 3 showed ineffective results. The cure rate was 81.97% and the total effective rate was 95.08% .In the control group，among 59 ears， 38 ears were recovered， 6 showed effectual results， 5 were positive to the treatment，10 showed ineffective results. The cure rate was 64.61% and the total effective rate was 83.05% . The therapeutic effect of experimental group was better than that of the control group. The complication rate of the experimental group was 9.84%，while the control group was 28.81%. The complication rate of the experimental group was significantly lower than that of the control group. The recurrence rate of the experimental group was 6.56% while the control group was 20.34%， the recurrence rate in the control group was significantly higher than that of the experimental group. The differences both had statistical significance (P<0.05). CONCLUSION The treatment of CSOM with salingocatheterism combined with Qingqiao tang irrigation under endoscope is effective and causes little injury. With a low recurring rate and less adverse reaction， this treating method is worth of being applied widely.