Abstract: OBJECTIVE To investigate the effect of Shuzheng granules on diabetic foot pain， ulcer healing and lower limb blood supply of the patients with diabetic foot after taking interventional treatment. METHODS Patients with diabetic foot who had taken interventional therapy successfully were randomly divided into Shuzheng granules treatment group (n=22) and basic treatment group (n=21). The two groups were given the same regular basic treatment while Shuzheng granules was added to the first group. Then the results including pain symptoms integral， ulcer healing extent， ankle-brachial index (ABI)， arterial flow velocity and the artery diameter before and after the treatment of the two groups were compared.RESULTS The improvement in pain symptoms integral depth of ulcer， ulcer area， ankle-brachial index， arterial blood flow velocity， arterial diameter and hemarheology were better in the treatment group (P<0.05).CONCLUSION ShuZheng granules combined with basic therapy has advantages in ulcer healing， pain relieving and lower limb blood flow increasing for patients with diabetic foot after intervention.