Abstract: OBJECTIVE To evaluate the efficacy and safety of Fufang Huangbai Liquid in treating acute and sub-acute aczema. METHODS 70 patients were randomly divided into experimental group and control group. Both groups were treated with compound triamcinolone acetonide cream， while experimental group were given Fufang Huangbai Liquid simultaneously for external use. Both drugs were given twice a day for two courses with two weeks in each. Clinical therapeutic effects and side effects in first and second week were observed. RESULTS Clinical efficiency was 88.9%（32/36）in experimental group， which was better than 67.6%（23/34）in the control group. There was an obvious difference between two groups（P<0.05）. Compared with control group， mean value of sign index of experimental group was distinctly lower， as well as the main symptoms. There was an obvious difference between two groups（P<0.05）. Lower frequency of drugs mainly manifested as transient stimulus response which can disappear in a short time. CONCLUSION Combination of steroid and glucocorticoid and Fufang Huangbai Liquid is safe and effective on treating acute and sub-acute aczema.