Abstract: OBJECTIVE To study the formation and preparation technology of Yangxue Ruanjian Tablet. METHODS The single-factor method was taken to optimize the pharmaceutical formulations and the content was selected by granulating difficulty， angle of repose， degree of surface smoothness， hardness and disintegration. RESULTS Fluidized-bed granulating， tabletting and coating the mixture of raw powder， microcrystalline cellulose(MCC)， Sodium carboxymethyl starch and dextrin were made according to the proportion of 300: 50: 6: 3: 1. CONCLUSION Yangxue Ruanjian Tablet is reasonable and the process is simple and feasible， which conforms to the requirements for production.