Abstract: OBJECTIVE To observe the efficacy of Danggui Sini Decoction in preventing and treating oxaliplatin neurotoxicity. METHODS 48 patients in accordance with criteria were randomly divided into treatment group and control group with 24 cases in each. All the patients had been treated with chemotherapy which contained oxaliplatin. Furthermore， treatment group were simultaneously given Danggui Sini Decoction. Each group was treated for four courses with 21 days in each course. The neurotoxicity classification and clinical therapeutic effect of Chinese Medicine were observed after treatment. RESULTS The total effective rate of TCM syndromes after therapy was 70.8% and 37.5% respectively in treatment group and the control group (P<0.05). The total incidence of neurotoxicity after therapy of the treatment group and the control group(P<0.05). CONCLUSION Danggui Sini Decoction is effective on preventing and treating oxaliplatin neurotoxicity.