Abstract: OBJECTIVE To evaluate the differences between point drug delivery's clinical effect on diarrhea-predominant irritable bowel syndrome due to yang insufficiency of both spleen and kidney and the western medicine effect. METHODS 58 patients were randomly divided into two groups by using simple random number table method. 29 cases in treatment group were undertaken drug delivery on Shenque point， of which there were 3 cases defluxion. 29 cases in control group took Decetel and Jinshuangqi of which there were 2 cases defluxion. Clinical curative effect comparison was done after treated for 4 weeks for these two groups and the effect on IBS-D patients belonging to yang insufficiency of both spleen and kidney was evaluated. RESULTS The total effective rate of treatment group was 88.46%， superior to control group of 62.96% (P<0.05). There was statistic significance between two groups (P<0.05). CONCLUSION Point drug delivery with the advantage of improving clinical symptoms is effective on IBS-D patients due to yang insufficiency of both spleen and kidney syndrome.