Abstract: OBJECTIVE To observe the clinical efficacy on the chronic rhinosinusitis patients treated by nasal irrigation with QingDouLing Mixture. METHODS 60 cases of chronic rhinosinusitis and nasal endoscopic surgery were randomly divided into treatment group and control group with 30 cases in each group. The control group had nasal irrigation by using 0.9% sodium chloride injection， treatment group had nasal irrigation by using 0.9% sodium chloride injection with QingDouLing Mixture added. Nasal mucociliary transport rates (MTR) in both groups were measured before and 1 month， 3 months and 6 months after operation respectively. Follow-up visiting was kept for over 6 months to observe the clinical curative effect of the two groups. RESULTS MTR in treatment group of postoperation for 1 month and 3 months was faster than that of the control group. There was significant difference between two groups (P<0.05). There was no significant difference on MTR between the two groups when 6 months (P>0.05). Compared 3 months with 6 months， after the operation the overall control rate and total effective rate in treatment group were significantly higher than that of the control group， with significant difference (P<0.05). CONCLUSION QingDouLing Mixture for nasal irrigation has good curative effect on many aspects， such as controlling the inflammation of the nasal cavity， reducing secretion， improving clinical symptoms， reducing the operation cavity edema to prevent granulation and vesicle formation， promoting the operation cavity epithelization， and promoting early recovery of nasal mucociliary function， etc.