大豆异黄酮对脑缺血再灌注大鼠海马神经再生的影响
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摘要: 目的 观察大豆异黄酮对脑缺血再灌注大鼠海马神经再生的影响。方法 线栓法建立大鼠脑缺血再灌注模型，分别给予大豆异黄酮（SI）、7硝基吲哚（7NI）或联合给药（SI+7NI），BrdU免疫荧光法标记新生海马神经细胞，免疫组化法检测海马区ONOO-的反应产物硝基酪氨酸（NT）。结果 SI组、7NI组和SI+7NI组大鼠海马区BrdU＋细胞数增加更显著，NT的数量明显减少（P<0.05，P<0.01）。结论 长期给予大豆异黄酮可以使脑缺血再灌注时病理性的ONOO-生成减少，并促进脑缺血组织的海马神经再生，这对脑缺血损伤有潜在的应用价值。
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