Abstract: To find the optimal preparation technique for oleum curcumae wenchowensis microballoon with orthogonal method. METHOD Orthogonal method was used to find the best technique, with the diameter of the microballoon, its distribution, drug-beating amount, envelop rate, etc. as the indexes. RESULT The microballoons prepared according to the optimal technique parameters assumed good appearance and the diameter conforms to the requirement for hepatic artery embolism, with an average drug-bearing rate of 9.45 %, envelop rate of 32.34%, an average yield rate of 85.19%, and good reproducibility. CONCLUSION The established preparation technique for 01eum curcumae wenchowensis microballoon is feasible.