Abstract: OBJECTIVE To investigate into the effect of Semen Sinapis Albae Liniment in the treatment of guinea pig asthma, compared with traditional preparations. METHOD Egg albumen was used to create guinea pig asthma models. Semen Sinapis Albae Liniment produced with modem pharmacological methods was applied to the back of the guinea pigs. RESULT The liniment eould markedly prolong asthma incubation period, relieve the severity of asthma attaek, shorten the duration of asthma and improve the pathological state of the lung tissue. However, the traditional preparations were superior to the liniment in the initial inducement of the ineubation period of asthma attack. CONCLUSION Semen Sinapis Albae Liniment has good effect in preventing and eontrolling the attack of experimental asthma and reducing the severity of the attaek. Though further researches are necessary, it already shows its advantages in the preparation form, which are worth studying and applying.