Abstract: OBJECTIVE To observe the effect of the Chinese drug Langchuangjing Granule in the treatment of the syndrome of kidney deficiency with damp toxin in patients with active lupus nephritis(LN).METHOD Forty LN patients were divided into a treatment group of 22 patients(treated with western medicine and Langchuangjing Granule) and a control group of 18 patients(treated with western medicine only) and were treated for 12 weeks.RESULT Good effect was obtained in relieving albuminuria in the patients with a level of <3.5g/24 h after the 8th day,and hematuria and SLEDAI integral started to be reduced markedly since the 4th week,with statistical significance between the two groups(P<0.05).Kidney function was improved.Better effect was obtained in the treatment group in relieving skin red patches,lumbago,palpitation caused by hormone and tremor of the hand (P<0.05).CONCLUSION Based on the immunity inhibition treatment with western medicine,Langchuangjing Granule is effective in controlling the condition of LN,relieving the clinical symptoms,reducing the side effect of western medicines,relieving albuminuria and hematuria,and improving the kidney function.