Abstract: OBJECTIVE To observe the effect of Mailuoning Dispersible Tablet on the survival rate,pathological changes,water content of the brain,brain index,brain NOS,SOD and MDA,and the content of protein in rats with multiple cerebral infarction.METHOD Rat multiple cerebral infarction models were made by temporarily clamping the common carotid artery and injecting embolus into the artery.RESULT The tablet could reduce the water contend in the brain,the brain indexes and the content of NOS,MDA and protein and increase SOD activity,with marked differences between the high dosage group(17 grams of crude drug/kg) and the model group(P<0.05).CONCLUSION Mailuoning Dispersible Tablet has therapeutic effect for rats with multiple cerebral infarction.