Abstract: OBJECTIVE To investigate into the effect of Herba Ephedrae on high-lipid rats. METHOD Automatic biochemical analyzer was used to detect the changes in the content of cholesterol in the blood of rats. RESUiT Herba Ephedrae could markedly reduce the content of cholesterol in the blood. CONCLUSION Herba Ephedrae has the effect of antagonizing hypercholesteremia and this effect is probably related to the effect of ephedrine.