Abstract: OBJECTIVE To evaluate the effect and safety of Tongluo Ningxin Oral Liquid in the treatment of unstable angina pectoris.METHOD Fifty-five patients with coronary heart disease and angina pectoris were randomly divided into two groups: a treatment group of 31 patients treated with Tongluo Ningxin Oral Liquid,and a control group of 24 patients treated with Compound Radix Salviae Miltiorrhizae Drop Pill for a month.RESULT The total effective rate of Tongluo Ningxin Oral Liquid was 58.06%,which is similar to 58.33% found in the control group,but the markedly effective rate was 19.35%,which is much higher than 8.89% in the control group.The oral liquid is also more satisfactory in the improvement of symptoms and heart function.CONCLUSION Tongluo Ningxin Oral Liquid is safe and markedly effective in the treatment of unstable angina pectoris and can relieve myocardial ischemia.