Abstract: OBJECTIVE To determine the optimal technique for preparing Chaiqin Liangjie Decoction with AB-8 resin.METHOD L_9(3~4) orthogonal method and HPLC were employed to determine the absorption and resolution rates of baicalin and jasminoidin.Using these as the indexes,the author carried out a study into the effect of drug concentration,resin amount and flow rate on absorption,and the effect of resolution solution concentration,volume and flow rate on resolution.RESULT The resolution rate of baicalin and jasminoidin could reach over 95% under the conditions of an absorption solution concentration of 0.15 grams of crude drug per milliliter,a resin amount of 3 times that of the drugs,a flow rate of 10 mL/min;and a resolution solution of 75% alcohol,a resin amount of 10 times that of the drugs and a flow rate of 10 mL/min.CONCLUSION The technique for preparing Chaiqin Liangjie Decoction with AB-8 is simple,stable and controllable.