Abstract: OBJECTIVE To investigate into the effect and safety of Yangjing Capsule in the treatment of oligospermatism.METHOD 245 patients with oligospermatism were randomly divided into a treatment group of 195 patients and a control group of 50 patients,who took Yangjing Capsule and Wuzi Yanzong Pill respectively for 90 days.RESULT The effective rates of the treatment group and control group were 88.68% and 71.11% respectively,with marked difference(P<0.01).The forward motility sperm increased gradually in the treatment group after the treatment,with marked difference as compared with the sperm count before the treatment(P<0.01).For patients with oligospermatism as a complication with a sperm density of over 5,000,000/mL,Yangjing Capsule could increase the sperm density,with marked difference as compared with the sperm count before the treatment(P<0.01).Seminal plasma fructose level was also increased,with marked difference as compared with the level before the treatment.No serious undesirable accident occurred in both group.CONCLUSION Yangjing Capsule is very effective for oligospermatism and can markedly increase sperm density for patients with a sperm density of over 5,000,000/mL,with no serious side effect.