山药及其麸炒品水提液不同极性部位对脾虚小鼠胃肠功能的影响

Effect of Radix Dioscoreae Oppositae and Water Extract of It Stir-baked with Bran on Gastrointestinal Function of Mice with Spleen Deficiency

    摘要
  • 摘要: 目的比较生山药及麸炒山药水提液不同极性部位对提高脾虚小鼠胃肠功能作用的差异。方法采用胃排空法及肠推进试验法,比较了生山药及其麸炒品水提液的不同极性部位对脾虚小鼠胃肠功能的影响。结果山药经麸炒后水提液二氯甲烷部位在抑制脾虚小鼠胃排空及肠推进作用较生品强。结论山药经麸炒后水提液二氯甲烷部位较生品有更强的抑制脾虚小鼠胃排空及肠推进作用,提示麸炒山药对脾虚小鼠胃肠功能作用的有效成份有可能存在与水提液的低级性部位,该实验为进一步阐明麸炒山药的炮制机理奠定了理论基础。

     

    Abstract: OBJECTIVE To compare between the effect of crude Radix Dioscoreae Oppositae and the water extract of the drug stir-baked with bran at different polarities on the gastrointestinal function of mice with spleen deficiency.METHOD Gastric emptying method and intestinal propelling method were used in the comparison.RESULT The water extract of stir-baked Radix Dioscoreae Oppositae at the location of dichlormethane had better effect in inhibiting mice gastric emptying and intestinal propelling than the crude drug.CONCLUSION The result of the study indicates that the effective component of stir-baked Radix Dioscoreae Oppositae might exist at the low polarity part of its water extract.This study has laid the theoretical foundation for further investigation on the mechanism of the preparation of stir-baked Radix Dioscoreae Oppositae.

     

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