Abstract: OBJECTIVE To observe the mechanism of Xuemaitong Granule on cervical artherosclerosis.METHOD Doppler ultrasound technique was adopted to choose 77 cervical artherosclerosis patients from those with hypertension or hyperlipemia,which were divided randomly into a treatment group and a control group,treated with Xuemaitong Granule(10 grams at a time,three times daily) and Simvastatin(20 mg/qn) respectively for 6 months.RESULT In both groups,the thickening of the middle layer of cervical endarterium did not develop further and the plaques were resolved,but with no marked difference as compared with the conditions before the treatment.In the treatment group,TG,LPa,ox-LDL,SOD,MDA and MMP-1 dropped greatly and HDL-C increased greatly,with marked statistical significance.No undesirable reactions were found in both groups.CONCLUSION Xuemaitong Graunle can effectively control blood lipid,improve the function of blood vessel endodermis and prevent the development of the plaques.