Abstract: The mixed stasis-heat syndrome occurs at a certain stage of development of acute exogenous febrile diseases or internal miscellaneous diseases,when heat,toxin and phlegm-dampness accumulate in the blood system,causing the formation of blood heat and blood stasis,which combine to form a special syndrome.The syndrome is caused by heat and toxin and is located deeply in the ying system and collaterals,manifested by damage to the zang-fu organs,and therefore should be treated by cooling blood and removing blood stasis.The authors carried out theoretical,clinical and experimental studies systematically on the stasis heat and water retention syndrome of patients with epidemic hemorrhagic fever and acute renal failure,stasis heat and jaundice syndrome of serious hepatitis patients,stasis heat and blood extravasation syndrome of hemorrhagic disease patients,syndrome of stasis heat blocking the orifice of hemorrhagic apoplexy patients and excessive heat and blood stasis syndrome of patients with hyperlipemia patients,which shows the feature of considering "syndromes" as the core in TCM research.