Abstract: OBJECTIVE To investigate into the anti-inflammatory effect of the total alkaloids part of Rhizoma Pinelliae Ternatae Praeparata.METHOD Observations were made on the anti-inflammatory effect of the total alkaloids part on mice models and determination was made on the PGE_2 content.RESULT The alkaloids in Rhizoma Pinelliae Ternatae Praeparata had marked inhibiting effect on auricle swelling of mice caused by xylene,increase of permeability of mice capillary caused by ethanoic acid,and the formation of granulation tumor in rats.The content of PGE_2 in the alkaloid group was greatly lower than that in the model group.CONCLUSION The total alkaloid part of Rhizoma Pinelliae Ternatae Praeparata has marked anti-inflammatory effect for multiple inflammation,which is related with the release and inhibition of the inflammation factor PGE_2.