Abstract: OBJECTIVE To investigate into the normal phase immunity-regulating effect of Sanwubai Powder in treating tumor.METHOD Subaxillary transplantation tumor models were made,treated with Sanwubai Powder in three different dosages,compared with a normal control group(saline group) and a positive medicine group (5-fluorouracil group).Eight days after drug administration,the tumors,thymus and spleen were taken and weighed and other indexes calculated.RESULT The tumor-inhibiting rates in the groups treated with medications were markedly different from those in the normal control group(P<0.01);no difference was found between the weights of thymus and spleen in the groups treated with Sanwubai Powder and the control group;in the 5-fluorouracil group,the weight of the spleen was markedly different from that in the control group(P<0.05);compared with the normal control group,IL-2 level rose(P<0.01) and IL-4 level dropped in the groups treated with Sanwubai Powder.CONCLUSION Sanwubai Powder has overall immunity-regulating effect in the treatment of tumor.