Abstract: OBJECTIVE To explore into the pharmacodynamic effect of rhinitis spray on rat models with allergic rhinitis. METHOD Allergic rhinitis rat models were made using 10% TDI olive oil,which were then treated with rhinitis spray made from Chinese medicine,compared with a control group treated with Livostin nose spray. RESULT The rhinitis spray made from Chinese medicine could effectively inhibit the pathological changes of nose membrane of rats with allergic rhinitis and reduce the content of thylamine in the nose membrane.CONCLUSION The rhinitis spray made from Chinese medicine has good effect in inhibiting or removing the symptoms of allergic rhinitis.