Abstract: Based on common problems in the research of pharmacology of traditional Chinese medical formulae and practice and results of laboratory work, this paper presents methodology in the research by combining the advantages of Chinese medicine and Chinese pharmacology, traditional theories and modern concepts, and theoretical basis and practice. The authors also deal with the regularities of drug combination, researches in biological effects, researches in the basis of active components in prescriptions, application of new technology in the study of pharmacology of traditional Chinese medical formulae, exploration of information resources of prescriptions, etc.