苇管灸改善血瘀耳窍证突发性聋患者基底动脉供血及预后的临床研究

Clinical Study of Reed Tube Moxibustion on Basilar Artery Blood Supply and Prognosis in Treating Sudden Sensorineural Hearing Loss with Blood Stasis in the Ear Orifice Syndrome

  • 摘要:
    目的 观察苇管灸对血瘀耳窍证突发性聋(SSNHL)患者基底动脉(BA)循环血供和临床疗效的影响。
    方法 采用简单随机对照设计将68例血瘀耳窍证SSNHL患者分为对照组、观察组,每组各34例。对照组给予临床标准化治疗方案,观察组在对照组治疗基础上联合苇管灸治疗。治疗前后比较2组患者VAS评分、中医证候积分、听力损失治疗有效率及复发率以综合评价临床疗效;使用经颅多普勒超声(TCD)测定BA舒张期血流速度(Vd)、收缩期血流速度(Vs)、平均血流速度(Vm)、血管搏动指数(PI)以及血管阻力指数(RI)以多维度评价患者BA循环血供的变化;采用Firth方法的Logistic回归分析临床疗效、BA血供特征的影响因素。
    结果 治疗后,观察组患者听力损失治疗有效率显著高于对照组(P<0.05);观察组耳闷VAS评分、耳鸣VAS评分及中医证候总积分均降低(P<0.05),观察组在听力下降积分、局部感觉异常、舌下瘀点瘀斑和中医证候总积分改善明显优于对照组(P<0.05);观察组BA的Vd、Vs、Vm水平均显著提高(P<0.01),对照组无显著改善(P>0.05)。Logistic回归分析结果提示苇管灸方案是耳闷、BA Vd、Vs和Vm的独立保护因素。
    结论 苇管灸方案能够有效改善血瘀耳窍证SSNHL听力损失及中医证候症状,改善患者耳闷预后,其疗效机制可能与调节BA循环供血状态相关。

     

    Abstract:
    OBJECTIVE To observe the effect of reed tube moxibustion on basilar artery (BA) blood circulation and clinical efficacy in patients with sudden sensorineural hearing loss (SSNHL) with blood stasis in the ear orifice syndrome.
    METHODS A simple randomized controlled design was used to divide 68 SSNHL patients with blood stasis in the ear orifice syndrome into a control group and an observation group, with 34 cases in each group. The control group received standardized treatment in accordance with the SSNHL guidelines (the “standard regimen”). The observation group received additional reed tube moxibustion on the basis of the control treatment (the “reed tube moxibustion regimen”). Before and after treatment, the two groups were compared in terms of VAS score, TCM syndrome score, effective rate of hearing loss treatment, and recurrence rate to comprehensively evaluate clinical efficacy. Transcranial Doppler ultrasonography (TCD) was used to measure BA diastolic blood flow velocity (Vd), systolic blood flow velocity (Vs), mean blood flow velocity (Vm), pulsatility index (PI), and resistance index (RI) to evaluate changes in BA circulation from multiple dimensions. Logistic regression with the Firth method was used to analyze influencing factors of clinical efficacy and BA blood supply characteristics.
    RESULTS After treatment, the effective rate of hearing loss in the observation group was significantly higher than that in the control group (P<0.05). Aural fullness VAS score, tinnitus VAS score, and total TCM syndrome score were decreased in the observation group (P<0.05), and the observation group was significantly superior to the control group in improving hearing loss score, local sensory abnormality scores, sublingual stasis spots scores, and total TCM syndrome scores (P<0.05). After treatment, BA Vd, Vs, and Vm were significantly increased in the observation group (P<0.01), but showed no improvement in the control group (P>0.05). Logistic regression analysis indicated that the reed tube moxibustion regimen was an independent protective factor for aural fullness, BA Vd, Vs, and Vm.
    CONCLUSION The reed tube moxibustion regimen effectively alleviates hearing loss and TCM syndrome symptoms in SSNHL patients with blood stasis in the ear orifice syndrome and improves the prognosis for aural fullness. Its therapeutic mechanism may be related to the regulation of blood supply in the basilar artery.

     

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