基于白色脂肪棕色化的辛热中药成分减肥作用研究进展

Research Progress on Anti-Obesity Effect of Components from Pungent-Hot Chinese Herbal Medicines Based on White Adipose Tissue Browning

  • 摘要: 辛热(含辛温)中药成分因其能温阳作用而能够有效治疗肥胖,其主要作用机制与促进白色脂肪棕色化相关。本文在概述白色脂肪棕色化作用的基础上,系统总结了近年来的辛热中药成分促进白色脂肪棕色化减肥作用及其机制,发现以辣椒素、桂皮醛为其主要代表性成分,并且存在与寒冷环境的协同作用。同时,本文探讨了辛热中药成分局部递送产热减肥的应用前景,并且提出了探索潜在新机制、协同应用前沿技术以及开发局部减肥外用药的展望,以期为辛热中药成分减肥应用开发提供科学依据,为基于脂肪细胞产热的辛热中药药性表征提供新思路。

     

    Abstract: Pungent-hot (including pungent-warm) components from Chinese herbal medicines can effectively treat obesity due to their yang-warming effect, and their main mechanism of action is related to promote white adipose tissue browning. On the basis of summarizing the role of white adipose tissue browning, this article systematically reviews the fat-reducing effect and mechanism of pungent-hot Chinese herbal components in promoting white adipose tissue browning in recent years, and finds that capsaicin and cinnamaldehyde are the main representative components, with a synergistic effect with cold environment. This article also focuses on discussing the application prospects of local delivery of pungent-hot Chinese herbal components for thermogenic fat reduction, and puts forward three aspects of prospects: exploring new mechanisms, applying new technologies, and developing sesquiterpene components for local fat reduction. This article will provide a scientific basis for the development of fat-reducing applications of pungent-hot Chinese herbal components, and offer new ideas for the medicinal property characterization of pungent-hot Chinese herbal medicines based on adipocyte thermogenesis.

     

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