Abstract: Malignant tumors represent a significant contributor to the increasing global burden of disease. Contemporary medical therapies often face challenges such as high recurrence rates and considerable adverse effects, making the exploration of more efficient and safer treatment strategies for cancer patients a current research priority. Traditional Chinese Medicine (TCM) has demonstrated unique value in oncology, exhibiting comprehensive advantages including multi-target effects, diverse active components, and low drug resistance, particularly in enhancing efficacy, reducing toxicity, improving prognosis, and elevating patients' quality of life. Through a literature review and based on the Cancer Toxin pathogenesis theory, this article systematically elaborates on the antitumor effects and underlying mechanisms of Qi-regulating and detoxifying Chinese medicines, aiming to provide new insights and scientific evidence for the TCM-based diagnosis and treatment of malignant tumors.