呼吸道合胞病毒的感染路径及其中药干预研究

Research on the Infection Pathway of Respiratory Syncytial Virus and Its Intervention with Traditional Chinese Medicine

  • 摘要: 呼吸道合胞病毒(Respiratory syncytial virus,RSV)及其诱发的急性呼吸道感染已成为全球重点公共卫生问题。然而现有抗病毒药不足,且存在耐药性、适用人群受限和毒副作用大等局限性,亟需研发新型治疗手段和药物。作为传统医学的重要组成部分,中药及其复方制剂在抗病毒领域中具有丰富的临床积累和潜在优势。其独特的作用靶点、多环节协同作用与RSV复杂的致病网络高度契合。本文旨在阐述RSV的感染路径与关键靶点,总结现有治疗手段的进展和不足,系统解析中药及其复方制剂对病毒感染不同环节的调控机制和成药潜力,为提升我国病毒防控能力和研制抗病毒新药提供参考。

     

    Abstract: Respiratory syncytial virus (RSV) and the acute respiratory infections it induced have become a global key public health issue. However, the existing antiviral drugs are insufficient and have limitations such as drug resistance, limited applicability, and high toxic side effects, which urgently require the development of new therapeutic methods and drugs. As an important part of traditional medicine, traditional Chinese medicine (TCM) and its compound preparations have rich clinical accumulation and potential advantages in the field of antiviral therapy. Their unique targets and multi-link synergistic effects are highly compatible with the complex pathogenic network of RSV. The article aims to describe the infection pathway and key targets of RSV, summarize the progress and shortcomings of existing therapeutic methods, and systematically analyze the regulatory mechanism and drug potential of TCM and its compound preparations on different stages of viral infection, so as to provide reference for improving the prevention and control capabilities and developing new antiviral drugs in China.

     

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