中药调控坏死性凋亡防治呼吸系统病毒感染性疾病

The Role of Traditional Chinese Medicine in Regulating Necroptosis to Prevent and Treat Respiratory Viral Infectious Diseases

  • 摘要: 呼吸系统感染性疾病在临床上极为常见,其中流感病毒感染引起的肺炎具有高发病率和死亡率的特点。目前针对呼吸系统病毒感染性疾病的临床治疗仍存在耐药性和疗效不佳等问题。坏死性凋亡作为程序性细胞死亡的一种形式,与呼吸系统病毒感染性疾病进程密切相关。中药调控细胞坏死性凋亡在呼吸系统病毒感染性疾病中展现出较好的治疗效果。本文对坏死性凋亡的概念及其机制、坏死性凋亡与呼吸系统病毒感染性疾病的关系以及中药调控坏死性凋亡干预呼吸系统病毒感染性疾病进展进行了综述,以期为呼吸系统病毒感染性疾病治疗药物的研发及临床应用提供参考。

     

    Abstract: Infectious diseases of the respiratory system are very common in clinical practice, among which pneumonia caused by influenza virus infection is characterized by high morbidity and mortality. Current clinical treatments for respiratory viral infections still face challenges such as drug resistance and poor efficacy. Necroptosis, a form of programmed cell death, is closely associated with the progression of respiratory viral infections. Traditional Chinese medicine modulating necroptosis has demonstrated beneficial therapeutic effects in these diseases. This paper introduces the concept and mechanisms of necroptosis, reviews recent research on the relationship between necroptosis and respiratory virus infections diseases, and summarizes the therapeutic effects of traditional Chinese medicine in regulating necroptosis to intervene in these diseases, aiming to provide insights for the development and clinical application of therapeutic agents for respiratory viral infections.

     

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