Abstract: Chinese medicine intestinal administration (CMIA) can avoid the degradation of drugs in gastric acid, bypass the first-pass effect of the liver, and deliver drugs directly to the lesion site. This approach increases local drug concentration, reduces drug dosage, and enhances bioavailability. This study systematically introduces the advantages, drug dosage forms, and whole-colon delivery technologies of CMIA for treating UC, and reviews its mechanisms of action, including repairing intestinal epithelial layer and mucous layer, regulating the intestinal microbiota, improving immune function, and promoting local blood circulation. It also analyzes the current progress and limitations of research, aiming to provide a more solid theoretical basis for the treatment of UC with Chinese medicine and to offer references for the development of UC therapeutic drugs and administration methods.