Abstract: This paper summarizes the academic thought and clinical experience of Professor Gu Ning in diagnosing and treating hyperuricemia (HUA) based on the Waterway Theory. He proposes that the waterway is a pathway regulated by the Sanjiao and multiple organs, responsible for body fluid metabolism, and that turbid fluids produced after metabolism must be excreted through this pathway. Based on the Water Theory, Professor Gu Ning proposes that the pathogenesis of HUA involves dysfunction of the organs and impaired waterway due to external exposure to the six exogenous pathogens or internal injuries from the seven emotions. The key pathological mechanism lies in the accumulation of dampness-turbidity, which subsequently gives rise to various syndrome patterns. Professor Gu Ning developed a therapeutic strategy of eliminating dampness and reducing turbidity for HUA based on the Waterway Theory. By combining and modifying two classical prescriptions, Simiao San and Wuling San, he formulated the Huashi Jiangzhuo Formula, offering a novel diagnostic and therapeutic approach as well as a theoretical foundation for the treatment of HUA.