Abstract: Drynaria fortunei, commonly known as "bone setting herb", has been widely included in various traditional Chinese herbal classics for treating bone injuries. It is used medicinally from its rhizome, which has a bitter taste and warm property. It is known to nourish the kidneys, strengthen bones, and alleviate pain from injuries. The chemical constituents mainly include flavonoids, phenylpropanoids, triterpenoids, phenolic acids, lignans, and sterols. Modern medical research indicates that Drynaria fortunei has anti-osteoporosis effects, promotes fracture healing, has anti-inflammatory properties, and benefits dental health. This article reviews the historical use of Drynaria fortunei and recent research on its chemical composition and pharmacological effects, summarizing some of the mechanisms of action. The aim is to provide a reference for further research on this medicinal herb.