基于脑玄府与胶质淋巴系统的相似性探讨抑郁症的病理机制

Exploring the Pathological Mechanism of Depression Based on the Similarity between the Brain Xuanfu and the Glymphatic System

  • 摘要: 提出脑玄府与胶质淋巴系统(Glymphatic system,GS)在生理结构上具有共通性,在转运脑内物质、传递脑内信息及清除代谢产物等功能上具有相似性。认为GS可能是脑玄府的实质性体现,GS功能障碍是抑郁症的关键病理环节,玄府闭郁、神机失用是抑郁症的核心病机。以“脑玄府-GS”为切入点,深入探讨抑郁症的病理机制,为抑郁症的中医临床诊疗提供理论依据。

     

    Abstract: It is proposed that the brain Xuanfu and the glymphatic system (GS) have commonality in physiological structure and similarity in functions such as transporting brain substances, transmitting brain information and clearing metabolites. It is believed that GS may be the substantial manifestation of the brain Xuanfu, and GS dysfunction is the key pathological link of depression. Xuanfu stagnation and Shenji dysfunction are the core pathogenesis of depression. Taking "Brain Xuanfu-GS" as the starting point, the pathological mechanism of depression is deeply explored, providing a theoretical basis for the clinical diagnosis and treatment of depression in traditional Chinese medicine.

     

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