Abstract: The qi-flavor compatibility theory originated from The Yellow Emperor's Inner Classic. This theory is based on yunqi theory, with qi as the core, and recognizes diseases from the imbalance of qi transformation in the internal and external environment of the human body; it combines four-qi and five-flavor theories, and jointly regulates the qi transformation of nature and the human body from the aspects of cold and heat and prosperity and decline; it emphasizes "carefully observing the qi rules and not missing the pathogenesis", and according to the prosperity and decline of yunqi and the cold and warm of the climate, the deficiency and excess of the viscus qi and the cold and heat of the disease, the flavor of medicine and food is used to resist the invasion of abnormal climate on the human body, and adjust the qi transformation of the five internal viscera, so that the human body can be restored to a state of qi activity harmony and yin and yang balance. The imbalance of yin and yang is the root cause of disease, with cold and heat as its manifestations, which are balanced by the four qi; prosperity and decline are the root causes, which are nourished and purged by the five flavors. The combination of four qi and the five flavors is essentially a multi-faceted adjustment of the imbalance of yin and yang in the human body. The mutual compatibility of multiple flavors can expand the scope of action of the drug, restrict the bias of the drug's flavor, and achieve both expelling evil and strengthening the body.