类器官技术在中医药领域的应用全景:从基础机制到临床实践的机遇与挑战

Panorama of Organoid Technologies in Chinese Medicine: Opportunities and Challenges from Basic Mechanisms to Clinical Practice

  • 摘要: 通过系统梳理类器官技术的发展历程及其在中医药领域的应用实例,结合文献分析,总结类器官在中医药机制与转化、病理机制、诊断技术和治疗策略中的具体应用,并评估其技术优势与局限性。类器官技术为中医药研究提供了高度模拟人体器官功能的体外模型,能够模拟中药多靶点、多途径的作用机制,显著提升了中医药在疾病机制解析、药物筛选和个性化治疗中的科学性和精准性。然而,其在标准化构建、伦理监管及临床转化方面仍面临挑战。类器官技术与中医药的结合具有广阔前景,未来需通过技术创新、跨学科合作和国际监管协调,进一步优化模型构建、解决伦理问题,并推动其在中医药研究和临床实践中的广泛应用。

     

    Abstract: By systematically reviewing the development history of organoid technology and its application examples in Chinese medicine, this paper summarizes the specific applications of organoids in the mechanism and translation of Chinese medicine, pathological mechanisms, diagnostic techniques, and therapeutic strategies, and evaluate their advantages and limitations through literature analysis. Organoid technology provides an in vitro model that highly simulates the function of human organs for TCM research, and can simulate the multi-target and multi-pathway mechanism of action of TCM, which significantly improves the scientificity and precision of TCM in the analysis of disease mechanisms, drug screening and personalized treatment. However, it still faces challenges in standardization, ethical regulation, and clinical translation. The combination of organoid technology and TCM has a broad prospect, and it is necessary to further optimize the model construction, resolve ethical issues, and promote its wide application in TCM research and clinical practice through technological innovation, interdisciplinary cooperation, and international regulatory coordination in the future.

     

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