Abstract: This paper summarizes the current status of research on the prevention and treatment of malignant tumors with traditional Chinese medicine (TCM), and points out that TCM has the advantages of being based on the holistic view and advocating the preventive treatment of diseases. The strategies of TCM in preventing and treating malignant tumors are proposed: first, it is necessary to clarify the leading or auxiliary treatment role in different stages of tumors and give full play to its strengths and advantages; second, find the characteristics of the superior and inferior populations and microscopic markers of tumor diagnosis and treatment to promote accurate diagnosis and treatment; third, improve the overall diagnosis and treatment level of tumors by grasping the core pathogenesis and ensure clinical efficacy; fourth, incorporate modern medical therapy factors into the TCM tumor diagnosis and treatment system in order to intercept the disease; fifth, add TCM psychological intervention on the basis of the four-in-one holistic syndrome differentiation view to achieve harmony between body and spirit; sixth, improve the rehabilitation and health care system of tumors combined with traditional Chinese and Western medicine through the use of multiple methods to promote the recovery of diseases. In this way, the clinical efficacy of TCM in preventing and treating tumors can be continuously improved, and the great goal of TCM in preventing and treating tumors and benefiting all mankind can be truly realized.